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(11)    Patent No :    AP 1913   
(21)    Application No :    AP/P/2004/003161   
(22)    Filing Date :    31.03.2003   
(24)    Date of Grant &    31.10.2008   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/369, 066    29.03.2002

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

NOVARTIS VACCINES AND DIAGNOSTICS, INC, 4560

Horton Street, Emeryville, CA 94608-2916,
United States of America

(72) Inventors

RENHOWE Paul A., United States Of America

RAMURTHY Savithri, United States of America

AMIRI Payman, United States of America

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   C07D 401/12 (2006.01)    C07D 401/14 (2006.01)
A61K 31/4439 (2006.01)    A61K 31/444 (2006.01)
A61K 31/4545 (2006.01)   

(54)    Title

Substituted benzazoles and use thereof as Raf kinase inhibitors

(57)    Abstract

New substituted benz-azole compounds of formula (I), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.


(56)    Documents Cited :    WO 00 62778 A    WO 01 66539 A

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