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(11)    Patent No :    AP 2775   
(21)    Application No :    AP/P/2010/005453   
(22)    Filing Date :    21.05.2009   
(24)    Date of Grant &    27.09.2013   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    61/055,661    23.05.2008
(84)    Designated State

BW    GM    GH    KE    LS    LR    MW  MZ  NA
SL    SD    SZ    TZ    UG    ZM    ZW
(73) Applicant(s)

WYETH LLC, Five Giralda Farms, Madison, New Jersey 07940,
United States of America
(72) Inventors

AYRAL-KALOUSTIAN Semiramis, United States of

CHEN Zecheng, United States of America
CURRAN Kevin Joseph, United States of America
et al
(74) Representative
(51)  International  Classification   C07D 498/08 (2006.01)    A61K 31/53 (2006.01)
A61P 35/00 (2006.01)   

(54)    Title

Triazine compounds as P13 kinase and MTOR inhibitors

(57)    Abstract

Compounds of formula I (I) wherein: R1 is (II) or (III); and R2, R4 and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit P13 kinase and mTOR, and may be used to treat diseases mediated by P13 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.

(56)  Documents Cited :    EP 1020462 A


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