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(11)    Patent No :    AP 2773    (73) Applicant(s)       
(21)    Application No :    AP/P/2006/003813    NANOBIOSYM, INC., 245 First Street, 18th Floor,       
            Cambridge, 02142, Massachusetts,       
(22)    Filing Date :    13.05.2005    United States of America       
(24)    Date of Grant &    27.09.2013           
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    GOEL Anita, United States of America   
    US            60/570,907        13.05.2004           
    US            60/616,793        06.10.2004    (74) Representative   
(84)    Designated State                   
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    FISHER CORMACK & BOTHA   
    SD    SZ    T Z    UG    ZM    ZW               
(51)    International    Classification    C12Q 1/68 (2006.01)    C12P 19/34 (2006.01)   
(54)    Title

NANO-PCR: Methods and devices for nucleic acid amplification and detection
(57)    Abstract

Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying stress to a nucleic acid. These methods can provide one ore more benefits over conventional PCR methods including: precision control over the PCR process; generally improved fidelity; improve d accuracy over problematic sequences such as GC-rich or tandem repeat regions; greater sequence length; increased reaction yield; reduced experimental time; greater efficiency; lower cost; greater portability; and, robustness to various environmental parameters, such as temperature, pH, and ionic strengths.

(56)    Documents Cited :    MAIER et al    US 4 965 188 A    US 5 753 439


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