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(11)    Patent No :    AP 2752   
(21)    Application No :    AP/P/2009/004881   
(22)    Filing Date :    21.11.2007   
(24)    Date of Grant &    06.09.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
IN    1931/MUM/2006    23.11.2006

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

CADILA PHARMACEUTICALS LTD, "Cadila Corporate

Campus", Sarkhej- Dholka Road, Bhat, Ahmedabad 382
210 Gujarat,

India
(72) Inventors

KHAMAR Bakulesh Mafatlal, India

MODI Indravadan Ambalal, India

(74) Representative

GALLOWAY & COMPANY
ZIMBABWE
(51)  International  Classification   A61K 39/04 (2006.01)    A61K 35/74 (2006.01)
C07K 1/35 (2006.01)   
(54)    Title

Poly-TLR antagonist

(57)    Abstract

Mycobacterium w or its components are found to have poly TLR antagonistic activity to induced TLRs by varieties of TLR ligands. The induced TLR against which inhibitory effect is seen includes TLR 3, 4, 5, 6, 7, 8, 9. They also display antagonistic activities to effects of TLR ligands. They are also useful in management of diseases wherein TLRs are over expressed, like sepsis, multiple sclerosis, optic neuritis, Chronic obstructive pulmonary diseases multiple myeloma etc.
(56)    Documents Cited :    FELESZCO W et al    WO 03/049667 A2

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