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(11)    Patent No :    AP 2745    (73) Applicant(s)       
(21)    Application No :    AP/P/2008/004352    NOVARTIS VACCINES AND DIAGNOSTICS SRL, Via       
            Fiorentina 1, I-53100 Siena,       
(22)    Filing Date :    02.08.2006    Italy       
(24)    Date of Grant &    05.09.2013           
(45)    Publication :

(30)    Priority Data                    (72) Inventors   
    (33) Country    (31) Number    (32) Date    CONTORNI Mario, Italy   
    GB            0515906.6        02.08.2005           
    GB            0522599.0        04.11.2005           
    GB            0523923.1        24.11.2005           
    et al                                   
                                (74) Representative   
(84)    Designated State                   
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    GILL, GODLONTON & GERRANS   
    SD    SZ    T Z    UG    ZM    ZW        ZIMBABWE       
(51)    International    Classification    A61K 39/39 (2006.01)    A61K 39/29 (2006.01)   
                            A61K 39/00 (2006.01)    A61K 36/185 (2006.01)
(54)    Title

Reducing interference between oil-containing adjuvants and surfactant -containing antigens

(57)    Abstract

Inclusion of fatty adjuvant in vaccine compositions can cause difficulties with certain antigenic components, particularly with antigens that include a surfactant component. A method for preparing an immunogenic composition comprising an antigen and a fatty adjuvant involves purification of the antigen

substantially in the absence of surfactant. Where surfactants cannot be avoided, the following are combined: (i) an antigen component that includes a surfactant and (ii) a fatty adjuvant component, to give a composition in which the weight ratio of said fatty adjuvant to said surfactant is less than

(56)    Documents Cited :    WO 00/03744 A2    US 3,435,112 A    DATABASE CA [Online] CHEMICAL ABSTRACTS



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