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(11)    Patent No :    AP 2743    (73) Applicant(s)       
(21)    Application No :    AP/P/2010/005521    TIBOTEC PHARMACEUTICALS, Eastgate Village, Eastgate,       
            Little Island, Co Cork,       
                   
(22)    Filing Date :    08.07.2009    Ireland       
(24)    Date of Grant &    04.09.2013           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    VENDEVILLE Sandrine Marie Hèlène, Belgium   
    EP            08159965.6    08.07.2008    RABOISSON Piere Jean-Marie Bernard, Belgium   
    EP            08160254.2    11.07.2008       
                        LIN Tse-1, Belgium   
    EP            08161743.3    04.08.2008       
                               
    et al                            et al       
                                (74) Representative   
(84)    Designated State                   
                           
    BW    GM    GH    KE    LS    LR    MW  MZ  NA    HONEY & BLANCKENBERG   
                                       
    SL    SD    SZ    TZ    UG    ZM    ZW           
(51)    International    Classification    C07D 513/18 (2006.01)    C07D 515/18 (2006.01)   
                            A61K 31/55 (2006.01)    A61P 31/14 (2006.01)
(54)    Title

Macrocyclic indole derivatives useful as hepatitis C virus inhibitors

(57)    Abstract

Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms and salts, hydrates, solvates thereof, wherein R1, R2, R4 R5, R6 and R7 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.

(56)    Documents Cited :    WO 2007/140200 A

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