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(11)    Patent No :    AP 2723   
(21)    Application No :    AP/P/2008/004388   
(22)    Filing Date :    06.09.2006   
(24)    Date of Grant &    16.08.2013   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/715,292    07.09.2005
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

AMGEN FREMONT INC., 6701 Kaiser Drive, Fremont, 94555
United States of America

PFIZER INC., 235 East 42nd Street, New York, NY 10017, United States of America

(72) Inventors

NORTH Michael Aidan, United States of America

AMUNDSON Karin Kristina, United States of


BEDIAN Vahe, United States of America

et al

(74) Representative

(51)  International  Classification   A61K 39/395 (2006.01)    C07K 16/40 (2006.01)
(54)    Title

Human monoclonal antibodies to activin receptor-like Kinase-1

(57)    Abstract

The present invention relates to antibodies including human antibodies and antigen -binding portions thereof that bind to the extracellular doman (ECD) of

activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates lo heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of makind human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic

(56)    Documents Cited :    R&D SYSTEMS    US 6,692,925 B1    MIYAZONO KOHEI et al    US 2005/0054019 A1

FERNANDEZ-L et al    US 5,968,752 A    US 2003/0152514 A1


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