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(11)    Patent No :    AP 2711   
(21)    Application No :    AP/P/2009/005037   
(22)    Filing Date :    09.05.2008   
(24)    Date of Grant &    30.07.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
ZA    2007/07360    10.05.2007

(84)    Designated State

BW    LS   MW  MZ   NA   SZ   UG   ZM  ZW
 
(73) Applicant(s)

UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG,

1 Jan Smuts Avenue, Johannesburg 2050,
South Africa
(72) Inventors

ALEXANDRE Kabamba, Bankoledi, South Africa

(74) Representative

FISHER CORMACK & BOTHA

(51)  International  Classification   A61K 31/132 (2006.01)    A61P 31/18 (2006.01)
A61K 31/7056 (2006.01)   
(54)    Title
A method of inhibiting HIV replication
(57)    Abstract
This invention relates to compounds and a method for inhibiting or treating HIV infection in a subject. The compounds are activators of AMP-activated protein kinase (AMPK) or pharmaceutically acceptable salts or derivatives of these activators. The activators of AMPK include metformin, metformin hydrochloride and AICAR.

(56)    Documents Cited : DRISCOLL SUSA D et al.    VAN WIJK JEROEN P H et al.    SRINIVAS, RANGA V et al.

GONG Y

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