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(11)    Patent No :    AP 2706   
(21)    Application No :    AP/P/2009/005072   
(22)    Filing Date :    26.06.2008   
(24)    Date of Grant &    29.07.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/937,726    29.06.2007
US    60/959,714    16.07.2007

(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   Z
(73) Applicant(s)

GILEAD SCIENCES, INC., 333 Lakeside Drive, Foster City,

CA 94404,
United States of America
(72) Inventors

GRAUPE Michael, United States of America

HALCOMB Randall L, United States of America

(74) Representative

HONEY & BLANCKENBERG
 
(51)  International  Classification   C07D 473/18 (2006.01)    A61K 31/522 (2006.01)
A61K 31/52 (2006.01)    A61P 31/12 (2006.01)


(54)    Title

Purine derivatives and their use as modulators of toll-like receptor 7

(57)    Abstract

The present application includes purine compounds of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the

administration of such compounds with at least one additional active agent.

(56)    Documents Cited :    US 2006/052403 A1    WO 2007/034817 A    WO 2007/034917 A

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