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(11)    Patent No :    AP 2702   
(21)    Application No :    AP/P/2008/004522   
(22)    Filing Date :    29.12.2006   
(24)    Date of Grant &    23.07.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/755,039    30.12.2005
US    60/756,631    06.01.2006
US    60/763,901    01.02.2006
et al

(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW
(73) Applicant(s)

GILEAD SCIENCES, INC., 333 Lakeside Drive, Foster City, CA 94404,
United States of America

JAPAN TOBACCO, INC, Pharmaceutical Division, 2-1, Toranomon 2- chome, Minato-ku, Tokyo 105-8422, Japan

(72) Inventors

KEARNEY Brian P, United States of America

KAKEE Atsuyuki, Japan

KAWAGUCHI Isao, Japan

t al
(74) Representative
HONEY & BLANCKENBERG
(51)  International  Classification   A61K 31/426 (2006.01)    A61K 31/47 (2006.01)
A61P 31/18 (2006.01)   
(4)    Title
Methods for improving the pharmacokinetics of HIV integrase inhibitors.
(57)    Abstract
The invention provides methods for improving the pharmacokinetics of an HIV

intergrase inhibiting compound by administering food and/or ritonavir or a pharmaceutically acceptable salt thereof with the HIV integrase inhibitor
(56)    Documents Cited :    WO 2005/112930 A    WO 2005/113508 A    EP 1 564 210 A    WO 2004/067531 A    WO

2004/101512 A    US 6 541 515 B2

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