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(11)    Patent No :    AP 1897   
(21)    Application No :    AP/P/2003/002829   
(22)    Filing Date :    22.01.2002   
(24)    Date of Grant &    10.10.2008   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/263,435    23.01.2001

(84)    Designated State

GM    GH    KE    LS   MW  MZ   SL   SD   SZ
T Z    UG    ZM    ZW

(73) Applicant(s)

AVENTIS PASTEUR, 1 Discovery Drive, Swiftwater, PA, 18370- 0187,
United States of America

(72) Inventors

RYALL Robert P, United States of America

(74) Representative

KAPLAN & STRATTON ADVOCATES
 

(51)  International  Classification   A61K 39/05 (2006.01)    A61K 39/095 (2006.01)
A61K 47/48 (2006.01)   


(54)    Title

Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine.

(57)    Abstract

The present invention describes a combined vaccine that offers broad protection against meningococcall disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W -135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to
(56)    Documents Cited : Giebink G.S et al: The Journal of Infectious Diseases (USA), Vol. 167, No.2, 07/02/93,

pp347-55, XP008015590   WO 98 45312 A

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