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(11)    Patent No :    AP 2692   
(21)    Application No :    AP/P/2007/004087   
(22)    Filing Date :    15.02.2006   
(24)    Date of Grant &    16.07.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
GB    0503337.8    17.02.2005

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

GLAXOSMITHKLINE BIOLOGICALS S.A., Rue De L'Institut

89, B-1330 Rixensart,
Belgium
72) Inventors
VANDE VELDE Vincent, Belgium
(74) Representative

GALLOWAY & COMPANY

ZIMBABWE

(51)  International  Classification   A61K 39/25 (2006.01)    A61P 1/00  (2006.01)
(54)    Title
Live attenuated rotavirus vaccine for oral administration
(57)    Abstract

The invention provides liquid rotavirus formulations that are suitable for oral administration to human infants. In particular the invention provides pharmaceutical compositions and vaccines, comprising a rotavirus antigen, a sugar and a carboxylate wherein said formulation has a pH of between pH 5.0

and pH 8.0 and comprises no phosphate or less than 5 mM phosphate. The invention also provides methods of preparing said rotavirus formulations and use thereof in the prevention or treatment of rotavirus associated diseases in
(56)    Documents Cited :    WO 02/11540 A    VESIKARI T et al:    WO 01/12797 A

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