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(11)    Patent No :    AP 2690   
(21)    Application No :    AP/P/2009/004784   
(22)    Filing Date :    21.08.2007   
(24)    Date of Grant &    15.07.2013   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
IN    1880/DEL/2006    22.08.2006
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)


32, Gurgaon- 122001, Haryana,
(72) Inventors

SATTIGERI Viswajanani J, India

PALLE Vekata P, India

KHERA Manoj Kumar, India
et al
(74) Representative
51)  International  Classification   C07D 209/48 (2006.01)    C07D 401/06 (2006.01)
A61K 31/4035 (2006.01)    A61P 29/00    (2006.01)
(54)    Title

Matrix metalloproteinase inhibitors

(57)    Abstract

The present invention relates to -hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ? -hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

(56)    Documents Cited :    WO 2006/090235 A    WO 2005/026120 A


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