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(11)    Patent No :    AP 2660   
(21)    Application No :    AP/P/2010/005435   
(22)    Filing Date :    25.03.2009   
(24)    Date of Grant &    13.05.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    08290278.4    26.03.2008
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 

(73) Applicant(s)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, 3, rue Michel-Ange, F-75794, Paris Cedex 16,
France

RUPRECHT- KARIS -UNIVERSITAT HEIDELBERG, Seminarstr.

Germany

(72) Inventors

DAVIOUD-CHARVET Elisabeth, France

MULLER Tobias, Germany

BAUER Holger, Germany
et al
(74) Representative
FISHER CORMACK & BOTHA
(51)    International  Classification   C07C 50/14 (2006.01)    C07C 50/24 (2006.01)
    C07C 50/32 (2006.01)    C07C 50/38 (2006.01)
    C07D 295/116 (2006.01)    C07D 295/096 (2006.01)
    A61K 31/04 (2006.01)    A61K 31/122 (2006.01)
    A61K 31/495 (2006.01)    A61P 33/06 (2006.01)
(54)    Title   

1,4-Naphthoquinone derivatives and therapeutic use thereof

(57)    Abstract

1,4-Naphthoquinone derivatives , of formula (I) wherein A is selected from the following rings: and their application as antimalarial agents.

(56)    Documents Cited :    HOWLAND JOHN L    BAUER HOLGER et al

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