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(11)    Patent No :    AP 1891    (73) Applicant(s)       
(21)    Application No :    AP/P/2001/002300    THE IMMUNE RESPONSE CORPORATION, 5935 Darwin       
            Court, Carlsbad, California 92008,       
                   
(22)    Filing Date :    05.05.2000    United States of America       
(24)    Date of Grant &    23.09.2008           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    MOSS Ronald B, United States of America   
    US            60/132,762    06.05.1999           
    US            60/150,667    25.08.1999    (74) Representative   
(84)    Designated State           
    GM    GH    KE    LS   MW  MZ    SL   SD   SZ    B. W. KAHARI LEGAL PRACTITIONERS   
    T Z    UG    ZW            ZIMBABWE       
                               
(51)    International    Classification    A61K 39/21 (2006.01)    A61P 31/18 (2006.01)   
                    A61K 39/21 (2006.01)       
(54)    Title

HIV immunogenic compositions and methods.

(57)    Abstract

The invention provides immunogenic compositions which enhance ?-chemokine levels in a mammal. The immunogenic compositions contain an

HIV antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant. The HIV antigen can be

a whole -killed HIV virus devoid of outer envelope protein gp120. Alternatively,

the HIV antigen can be a whole -killed HIV virus, or a p24 antigen. Also provided are kits, the components of which, when combined, produce the

immunogenic compositions of the invention. The invention also provides methods of making the immunogenic compositions, by combining an HIV

antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant. The invention further provides a method of immunizing a mammal, by enhancing b-chemokine production in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an isolated nucleic acid molecule containing an immunostimulatory sequence (ISS) and an adjuvant. Also provided is a method of inhibiting aids, by enhancing ?-chemokine production in the mammal by administering to the mammal an immunogenic composition containing an HIV antigen, an isolated nucleic acid molecule containing an


(56)    Documents Cited :    WO 98 55495 A    Vaccine, GB, Butterworth Scientific. Guildford, Vol. 16, No. 7,1.    Vaccine,

Vol. 18, No.11-12, 01/2000

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