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(11)    Patent No :    AP 2633   
(21)    Application No :    AP/P/2010/005405   
(22)    Filing Date :    31.10.2008   
(24)    Date of Grant &    03.04.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
IN    768/DEL/2008    26.03.2008
(84)    Designated State

BW    GM    GH    KE    LS    LR    MW  MZ  NA
SL    SD    SZ    TZ    UG    ZM    ZW
(73) Applicant(s)
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH,

Anusandhan Bhawan, 2, Rafi Marg, New Delhi 110 001,
India
(72) Inventors

SINGH Chandan, India

VERMA Ved Prakash, India

PURI Sunil Kumar, India

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   C07D 232/06 (2006.01)    A61P 33/06 (2006.01)
A61K 31/357 (2006.01)   
(54)    Title
Novel hydroxy functionalized 1,2,4-trioxanes as antimalarial agents  and a process for the preparation thereof

(57)    Abstract

The present invention relates to novel hydroxy functionalized 1, 2, 4-trioxanes of general formula (7) useful as antimalarial agents. This invention also relates to a process for the preparation of novel hydroxy functionalized 1,

2,4-

trioxanes and their derivatives. More particularly the present mvention provides a process for the preparation of hydroxy functionalized 1, 2,

4-trioxanes and their derivatives of general formula (7) wherein R1 and R2 represents methyl, or part of a cyclic system such as cyclopentane, cyclohexane, cycloheptane, adamantane and A is a spacer such as oxygen substituted aromatic moieties and R3 is CH2CH2OH or CH2CH2OCOCH2CH2COOH.These novel hydroxy functionalized 1, 2,

4-trioxanes and their derivatives of general formula (7) are new compounds and are useful as antimalarial agents. These compounds have been tested against multi-drug resistant malaria in mice and have shown promising

(56)    Documents Cited :    SING C et al    WO 03/082852 A    SINGH C et al

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