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(11)    Patent No :    AP 2632   
(21)    Application No :    AP/P/2005/003384   
(22)    Filing Date :    30.01.2004   
(24)    Date of Grant &    01.04.2013   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
BR    PI0303266-3    31.01.2003
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)


4365, Manguinhos, CEP-21045-900 Rio De Janeiro, RJ,
(72) Inventors
TENDLER Miriam, Brazil
KATZ Naftale, Brazil
SIMPSON Andrew J, Brazil
et al
(74) Representative

(51)  International  Classification   A61K 38/17 (2006.01)    C61K 39/00 (2006.01)
A61K 39/39 (2006.01)    C12N 15/12 (2006.01)
(54)    Title
Helminth-derived antigens having capacity of providing protection against parasites

(57)    Abstract

The primary objective of the present invention is the development of new mutant forms of the Sml4 protein, for producing a greater production volume. The recombinant proteins here obtained were capable of providing protection against schistosome and fasciola infection. The level of protection of Sml4 recombinant proteins obtained in the present invention was similar to that reached in the parasite saline extract. The mutant proteins of the present invention have reached approximately 100% of renaturation after the heating at 80°C, different from wild forms of the Sml4 protein. Moreover, after storage for 2 months at 4°C, mutant proteins have shown smaller


loss than wild forms that have shown formation with random structure, as demonstrated by the circular dichroism analysis, indicating the success of

(56)    Documents Cited :    GB-A-2285 626 A    MOSER D; et al    RAMOS C.R.R et al


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