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(11)    Patent No :    AP 2579   
(21)    Application No :    AP/P/2009/004859   
(22)    Filing Date :    15.11.2007   
(24)    Date of Grant &    29.01.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/858,939    15.11.2006
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

VIROCHEM PHARMA INC., 275 Armand Frappier Boulevard,

Laval, Quebec H7V 4A7,
Canada
(72) Inventors

CHAN CHUN KONG Laval, Canada

KUMAR DAS Sanjoy, Canada

POISSON Carl, Canada

et al

(74) Representative

FISHER CORMACK & BOTHA

(51)    International  Classification   C07D 409/12 (2006.01)    A61K 31/381 (2006.01)
    A61K 31/4196 (2006.01)    A61K 31/4535 (2006.01)
    A61K 31/7056 (2006.01)    A61K 38/21 (2006.01)
    A61P 31/14 (2006.01)    C07D 333/40 (2006.01)
    C07F 7/10 (2006.01)   
(54)    Title   

Thiophene analogues for the treatment or prevention of flavivirus infections

(57)    Abstract

Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections

(56)    Documents Cited :    WO 2006/072348 A2

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