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(11)    Patent No :    AP 1882   
(21)    Application No :    AP/P/2005/003306   
(22)    Filing Date :    03.11.2003   
(24)    Date of Grant &    21.08.2008               
(45)    Publication :
(30)  Priority Data       
(33) Country    (31) Number    (32) Date
GB    0225701.2    03.11.2002
(84)    Designated State

BW    GM    GH    KE    LS   MW  MZ   SL   SD
SZ    T Z    UG    ZM    ZW
 
(73) Applicant(s)

CIPLA LIMITED, 289 Bellasis Road, Mumbai Central,

Mumbai, 400 008,
India

(72) Inventors

RAO Dharmaraj Ramachandra, India

KANKAN Rajendra Narayanrao, India

(74) Representative

FISHER CORMACK & BOTHA
 

(51)  International  Classification   C07D 277/82 (2006.01)    C07D 277/00 (2006.01)


(54)    Title

Process for preparing 2,6-diamino-4,5,6,7-tetrahydro -Benzothiazole

(57)    Abstract

2,6-diamino-4,5,6,7-tetrahydro -benzothiazole, which is useful for making pramipexole, is made by: (i) reacting bromine with a solution of

4-acetamido-cyclohexanone in water to produce

2-bromo-4-acetamido-cyclohexanone; (ii) after step (i), adding thiourea to produce 6-acetyl amino-2-amino-4,5,6,7-tetrahydro-benzthiazole; (iii) after step (ii), adding an aqueous solution of hydrobromic acid to produce

2,6-diamino-4,5,6,7-tetrahydro -benzthiazole dihydrobromide; and (iv) after step (iii), isolating 2,6-diamino-4,5,6,7-tetrahydro -benzthiazole.



(56)    Documents Cited :    EP 0 186 087 A   J. of Tetrahedron, Elservier Science Publishers Amsterdam, NL. Vol. 2, 1958,

pp64-74.

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