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(11)    Patent No :    AP 2502   
(21)    Application No :    AP/P/2009/004931   
(22)    Filing Date :    28.12.2007   
(24)    Date of Grant &    23.10.2012   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/878,503    03.01.2007
US    60/921,433    02.04.2007

(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW

(73) Applicant(s)

LES LABORATOIRES SERVIER, 12 Place de la Défense, 92415, Courbevoie Cedex,

CORTEX PHARMACEUTICALS, INC, 15241 Barranca Parkway, Irvine, California 92718,

United States of America

(72) Inventors

CORDI Alexis, France

ROGERS Gary, United States of America

MUELLER Rudolf, United States of America

et al

(74) Representative


(51)  International  Classification   A01N 57/00 (2006.01)    A61K 31/675 (2006.01)

(54)    Title

3-substituted -[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

(57)    Abstract

This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to a compound useful for treatment of such conditions, and methods of using this compound for such t reatment

(56)    Documents Cited :    US 5 962 477 A    MURRAY et al    US 6 303 542 B1


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