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(11)    Patent No :    AP 2403   
(21)    Application No :    AP/P/2008/004401   
(22)    Filing Date :    16.10.2006   
(24)    Date of Grant &    04.05.2012   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/730,996    27.10.2005

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 

(73) Applicant(s)

PFIZER PRODUCTS INC., Eastern Point Road, Groton, CT 06340,
United States of America

(72) Inventors

BUTLER Todd William, United States of America

CHANDRASEKARAN Ramalakshmi, Yegna, United

States of America

WAGER Travis, T, United States of America

et al

(74) Representative

GALLOWAY & COMPANY

ZIMBABWE
 

(51)  International  Classification   C07C 237/24 (2006.01)    A61K 31/165 (2006.01)
C07D 207/04 (2006.01)   

(54)    Title

Histamine-3 receptor antagonists

(57)    Abstract

This invention is directed to a compound of formula as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a process of preparation of a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), psychotic disorders, cognitive disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro - intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above

(56)    Documents Cited :    US 6 559 140 B2    WO 2005/080361 A

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