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(11)    Patent No :    AP 2393   
(21)    Application No :    AP/P/2004/003081   
(22)    Filing Date :    08.02.2002   
(24)    Date of Grant &    04.04.2012   
           
(45)    Publication :

(30)    Priority Data

(33) Country  (31) Number   (32) Date
(84)    Designated State

KE   UG
 (73) Applicant(s)

VARIATION BIOTECHNOLOGIES INC., 200 rue Montcalm, Suite 400, Gatineau, Quebec J8Y 3B5,
Canada

(72) Inventors

TORRES José Vidal, United States of America

(74) Representative

HONEY & BLANCKENBERG
 
(51)  International  Classification   A61K 39/29 (2006.01)    A61K 39/00 (2006.01)
A61K 39/285 (2006.01)    A61K 39/01 (2006.01)
C12N 15/36 (2006.01)    C07K 14/02 (2006.01)
C07H 21/04 (2006.01)    C07K 14/09 (2006.01)
C07K 14/15 (2006.01)   

(54)    Title

Immunogenic formulations of variable peptidic epitopes and process for preparation thereof.

(57)    Abstract

A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from a pathogen. The mixture is termed a hypervariable epitope construct (HBC). Immunization with a HEC evokes broadly reactive immunity against divergent strains of a pathogen upon which the HEC is based.

(56)    Documents Cited :    ANDERSON DAVID E et al: Clinical Immunology (Orlando), vol. 101, no.2, Nov. 2001   CALOS

MARIA P et al: AIDS Research and Human Retroviruses, vol. 16, No. 2   MEYER DEBRA et
al:Viral Immunology    WO 94 00151

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