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(11)    Patent No :    AP 2388   
(21)    Application No :    AP/P/2005/003344   
(22)    Filing Date :    16.12.2003   
(24)    Date of Grant &    27.03.2012   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
CN    02156785.9    18.12.2002
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

BEIJING SOLOBIO GENETECHNOLOGY COMPANY LTD, No. 5 Rongjing East St. BDA 100176, Beijing,
Peoples Republic of China
(72) Inventors

ZHOU Zhiwen, China

FENG Yuxia, China

ZUO Conglin, China

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   C12N 15/113 (2006.01)    C12N 15/11 (2006.01)
A61P 31/18 (2006.01)   


(54)    Title

A group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof

(57)    Abstract

The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to

the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.

(56)    Documents Cited :    PARK WEE-SUNG et al    CAPODICI J    YAMAMOTO T et al    WO 2003/070193    WO

1999/09154    JACQUE J-M et al

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