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(11)    Patent No :    AP 2387    (73) Applicant(s)       
(21)    Application No :    AP/P/2008/004304    TIBOTEC PHARMACEUTICALS LTD., Eastgate Village,       
            Eastgate, Little Island, Co Cork,       
                   
(22)    Filing Date :    28.07.2006    Ireland       
(24)    Date of Grant &        MEDIVIR AB, Lunastigen 7, S-141 44 Huddinge,       
        26.03.2012    Sweden       
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    DE KOCK Herman Augustinus, Belgium   
    EP            05107066.2    29.07.2005    RABOISSON Pierre Jean-Marie Bernard, Belgium   
    EP            06101278.7    03.02.2006       
                        SIMMEN Kenneth Alan, Belgium   
                                   
                                et al       
                                (74) Representative   
(84)    Designated State                   
                           
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    HONEY & BLANCKENBERG   
    SD    SZ    T Z    UG    ZM    ZW               
(51)    International    Classification    A61K 31/4709 (2006.01)    A61P 31/14 (2006.01)   
                            C07K 5/06 (2006.01)       
(54)    Title

Macrocyclic inhibitors of hepatitis C virus

(57)    Abstract

Inhibitors of HCV of formula (I), and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1 -6alkyl; and n is 3,4,5, or 6; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

(56)    Documents Cited :    WO 2005/073195    WO 00/59929    WO 2005/073216

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