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(11)    Patent No :    AP 2386   
(21)    Application No :    AP/P/2008/004303   
(22)    Filing Date :    26.06.2006   
(24)    Date of Grant &    23.03.2012   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    05105762.8    28.06.2005

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)


B-2340 Beerse,
(72) Inventors

ANDRIES Koenraad Jozef Lodewijk Marcel, Belgium

KOUL Anil, Belgium

GUILLEMONT Jérôme Emile Georges, France

et al

(74) Representative

(51)  International  Classification   A61K 31/47 (2006.01)    A61P 31/04 (2006.01)
C07D 215/22 (2006.01)   
(54)    Title

Quinoline derivatives as antibacterial agents.

(57)    Abstract

Use of a compound for the manufacture of a medicament for the treatment of

a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (la) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric

form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula ; R3 is alkyl, Ar, Ar-alkyl, Het or

Het -alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl) or di(Ar)alkyl ; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula -

CH=CH-CH=CH-; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo ; or R8 and R9 together form the radical

(56)    Documents Cited :    WO 2004/011436    DESAI P K ET AL    WO 2005/033108    WO 2005/117875    WO



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