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(11)    Patent No :    AP 2385    (73) Applicant(s)       
(21)    Application No :    AP/P/2005/003438    PFIZER PRODUCTS INC., Eastern Point Road, Groton,       
            Connecticut 06340,       
                   
(22)    Filing Date :    08.12.2003    United States of America       
(24)    Date of Grant &    23.03.2012           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    KATH John Charles, United States of America   
    US    60/435,670    20.12.2003    LUZZIO Michael Joseph, United States of America   
    US    60/500,742    05.09.2003       
                (74) Representative   
(84)    Designated State           
    BW  GM  GH    KE   LS   MW    MZ   SL   SD    GALLOWAY & COMPANY   
    SZ   T Z   UG   ZM   ZW               
(51)    International    Classification    C07D 403/12 (2006.01)    C07D 401/14 (2006.01)   
            C07D 417/14 (2006.01)    C07D 413/14 (2006.01)   
            C07D 403/14 (2006.01)    C07D 405/14 (2006.01)   
            A61K 31/505 (2006.01)       

(54)    Title

Pyrimidine derivatives for the treatment of abnormal cell growth

(57)    Abstract

The present invention relates to a compound of the formula (I), wherein

R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in retreatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compound; in the treatment of abnormal cell growth in mammals. Especially humans, and to pharmaceutical compositions containing such compounds.

(56)  Documents Cited :    WO 03 032997    US 5 521 184    WO 97 19065WO 01    60816WO 00 39101
    KNOCKAERT, MARIE ET ALKATH J CSTOVER D R  ET    ALBRAMSON, H. NEAL ET AL

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