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(11)    Patent No :    AP 2384   
(21)    Application No :    AP/P/2008/004589   
(22)    Filing Date :    26.08.2008   
(24)    Date of Grant &    21.03.2012   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
FR    07.06346    11.09.2007
(45)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

LES LABORATOIRES SERVIER, 12 Place de la Defense, 92415, Courbevoie Cedex,
(72) Inventors

PEGLION Jean-Louis, France

GOUMENT Bertrand, France

DESSINGES Aimèe, France

et al

(74) Representative


(51)  International  Classification   A61K 31/357 (2006.01)    A61K 31/138 (2006.01)
A61K 31/343 (2006.01)   

(54)    Title

1,2,4,5- tetrahydro -3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them

(57)    Abstract

Compunds of the formula wherein R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxyl, methyl,-OSO2 R10, -OCOR10 or optionally substituted alkoxy group, or R2 and R3 , or R3 and R4, or R4 and R5 together form a group -O-(CH2)q -O-, -O-CH=CH-O- or

O-CH=CH-,-R6, R7, R8 and R9, each represent a hydrogen atom or an alkoxy group, or R6 and R7 or R7, and R8 or R8 and R9 together form a group

-O-(CH2)q -O-, R10 represents a group selected from linear or branched C1-C6 alkoxy, NR11 R`11 and optionally su bstituted alkyl,-R11 and R'11

represent a hydrogen atom or an alkyl group, or R11 and  R'11 together with

the nitrogen atom carry them form an optionally substituted , monocyclic or bicyclic, nitrogen-containing heterocycle,-X represents O, NH or CH2,-m and p

each represent 0 or 1,-n and q each represent 1 or 2, in racemic form or in the form of optical isomers, and also addition salts thereof with a

(56)    Documents Cited :    EP 0 534 859 A   EP 0 161 604 A   WO 2006/092491 A


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