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(11)    Patent No :    AP 1872    (73) Applicant(s)       
(21)    Application No :    AP/P/2004/003136    GLAXOSMITHKLINE BIOLOGICALS S.A., Rue De L'Institut       
            89, B-1330 Rixensart,       
                   
(22)    Filing Date :    17.03.2003    Belgium       
(24)    Date of Grant &    04.08.2008           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    WETTENDORFF Martine Anne Cecile, Belgium   
    GB    0206360.0    18.03.2002    (74) Representative   
(84)    Designated State           
                   
    GM  GH   KE    LS   MW  MZ    SL   SD   SZ    GALLOWAY & COMPANY   
    T Z   UG   ZM   ZW               
(51)    International    Classification    A61K 39/12 (2006.01)    C07K 14/025 (2006.01)   
            C12N 7/04 (2006.01)   

(54)    Title

Virus-like particles of human papillomavirus.

(57)    Abstract

The present invention relates to a vaccine composition comprising VLPs containing L1 proteins or functional L1 protein derivatives from HPV 16, HPV 18, HPV 31 and HPV 45 genotypes.

(56) Documents Cited : WO 95 31532 A US 6 066 324 A Wheeler C.: salud publica De mexico 1997, pp283-7 WO

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