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(11)    Patent No :    AP 2362   
(21)    Application No :    AP/P/2007/004043   
(22)    Filing Date :    22.12.2005   
(24)    Date of Grant &    08.02.2012   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/642,058    07.01.2005
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

PFIZER PRODUCTS INC., Eastern Point Road, Groton,

Connecticut 06340,
United States of America

(72) Inventors

HELAL Christopher John, United States of America

HOOVER Denis Jay, United States of America

HUMPHREY John Michael, United States of America

et al

(74) Representative



(51)  International  Classification   C07D 401/14 (2006.01)    C07D 413/14 (2006.01)
A61K 31/14 (2006.01)    A61P 25/18 (2006.01)

(54)    Title

Heteroaromatic quinoline compounds and their use as PDE10 inhibitors

(57)    Abstract

The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterese (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates fo r preparation of said compounds; pharmaceutica) compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorden.

(56)    Documents Cited :    WO 03/000269 A    WO 03/093499 A    WO 2005/120514 A


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