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(11)    Patent No :    AP 2361   
(21)    Application No :    AP/P/2007/004280   
(22)    Filing Date :    07.07.2006   
(24)    Date of Grant &    06.02.2012   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
FR    05/07,240    07.07.2005
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

SANOFI PASTEUR, 2 avenue Pont Pasteur, F-69367, Lyon Cedex 07,
France
(72) Inventors

KLUCKER Marie-Francoise, France

DALENCON Francois, France

PROBECK- QUELLEC Patricia, France

et al

(74) Representative

KAPLAN & STRATTON ADVOCATES
 

(51)  International  Classification   A61K 39/145 (2006.01)    A61K 39/39 (2006.01)



(54)    Title

Immunological adjuvant emulsion

(57)    Abstract

Vaccine composition comprising a thermoreversible emulsion. The subject of the invention is a vaccine composition comprising at least one vaccine antigen, and an oil-in-wrater emulsion comprising at least: squalene, a nonionic surfactant comprising ethylene oxide groups, with the exception of copolymers of polyoxyethylene and of polyoxypropylene, a ydrophobic nonionic surfactant, wherein the emulsion is thermoreversible and

wherein 90% of the population by volume of the oil drops has a size less than 200 nm.
(56)    Documents Cited :    US 6 299 884 B1    US 6 787 523 B1    US 2003/022852 A1

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