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(11)    Patent No :    AP 2353    (73) Applicant(s)       
(21)    Application No :    AP/P/2006/003772    WARNER-LAMBERT COMPANY LLC, 201 Tabor Road,       
            Morris       
                   
(22)    Filing Date :    19.04.2005    United States of America       
(24)    Date of Grant &    16.02.2012           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    BERNARDELLI Patrick, United Kingdom   
    EP            04291187.5    07.05.2004    CRONIN Andrew, Michael, United Kingdom   
    GB            0504564.6    04.03.2005       
                        DENIS Alexis, United Kingdom   
                           
                        et al       
                        (74) Representative   
(84)    Designated State           
                   
    GM    GH    KE    LS   MW  MZ    SL   SD   SZ    GALLOWAY & COMPANY   
    T Z    UG    ZW            ZIMBABWE       
                               
(51)    International    Classification    C07D295/135 (2006.01)    C07D205/155 (2006.01)   
                    C07D295/26 (2006.01)       


(54)    Title

3- or 4 -monosubstituted phenol and thiophenol derivatives useful as H3 ligands

(57)    Abstract

The invention relates to 3- or 4 -monosubstituted phenol and thiophenol derivatives of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3-or 4 -monosubstituted phenol and thiophenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

(56)    Documents Cited :    WO 02 06223    WO 02 076925    EP 0 269363    WO 02 12190    DE 3024836

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