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(11)    Patent No :    AP 2351   
(21)    Application No :    AP/P/2007/003990   
(22)    Filing Date :    12.10.2005   
(24)    Date of Grant &    25.01.2012   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    04105005.5    13.10.2004
US    60/618,469    13.10.2004
US    60/697,724    08.07.2005

et al

(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW
 

(73) Applicant(s)

CRUCELL HOLLAND B.V., Archimedesweg 4, NL- 2333 CN

Leiden,
The Netherlands

BETH ISRAEL DEACONESS MEDICAL CENTER INC., 330
Brookline Avenue, Brookline, Massachusetts, MA 02215,

United States of America

(72) Inventors

HAVENGA Menzo Jans Emco, The Netherlands

BAROUCH Dan, United States of America

(74) Representative

HONEY & BLANCKENBERG

(51)  International  Classification   C12N 15/861 (2006.01)    A61K 48/00 (2006.01)

(54)    Title

Improved adenoviral vectors and uses thereof

(57)    Abstract

The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre -existing immunity in a minority of the human

population and which harbour a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus and Adenovirus Receptor (CAR) and a hexon protein from an adenovirus serotype that encounters

(56)    Documents Cited :    US 60/618,469    US 60/697 724    US 04105005.5    PCT/EP2005/055183

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