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(11)    Patent No :    AP 2343   
(21)    Application No :    AP/P/2006/003752   
(22)    Filing Date :    11.03.2005   
(24)    Date of Grant &    28.12.2011   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    pct/ep04/00366    11.03.2004
    3   

(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW
 

(73) Applicant(s)

LABORATOIRES PHARMACEUTIQUES RODAEL, 1 Route de Socx, 59380, Bierne,
France

NUTRISET, Bois Ricard, F -76770 Malaunay, France


(72) Inventors

EQUIPART Paul, France


(74) Representative

FISHER CORMACK & BOTHA
 

(51)  International  Classification   A61K9/16 (2006.01)    A61K9/20 (2006.01)
A61K31/505 (2006.01)   


(54)    Title

Rapidly disintegrating taste-masked tablet

(57)    Abstract

The present invention concerns a rapidly disintegrating taste-masked tablet comprising: at least one active principle selected from the group comprising mineral salts, vitamins, and mixtures thereof, at least one sweetening agent, preferably a low calorie and anticariogenic sugar substitute selected from the

group comprising saccharin, cyclamate, aspartame, acesulfame K and alitame, preferably aspartame, optionally at least one flavouring agent, preferably a synthetic flavouring agent, starch and microcrystalline cellulose, which are binding agents with disintegrating properties, at least one free flow aid, and preferably colloidal silicon dioxide, and optionally at least one lubricating agent, selected in the group comprising magnesium stearate, micronized stearic acid and talc, and preferably magnesium stearate, characterized in that: the active principle is coated by the sweetening agent, and optionally, the flavouring agent, the weight ratio of the sweetening agent to the active principle ranges from 0.2 to 3, preferably from 0.2 to 2.1, and more preferably from 0.6 to 1.8, the weight ratio of starch to microcrystalline cellulose ranges from about 0.76 to 0.85, and preferably about 0.8. It also

(56)    Documents Cited :    US 6475510 B1    WO 0922464 A    EP 1203580

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