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(11)    Patent No :    AP 2336    (73) Applicant(s)       
(21)    Application No :    AP/P/2007/003898    JANSSEN PHARMACEUTICA N.V., Turnhoutseweg 30,       
            B-2340 Beerse,       
                   
(22)    Filing Date :    25.07.2005    Belgium       
(24)    Date of Grant &    08.12.2011           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    VERDONCK Marc Gustaaf Celine, Belgium   
    EP            04077172.7    28.07.2004    ANGIBAUD Patrick Rene, France   
    US            60/592,182        29.07.2004       
                            ROUX Bruno, France   
                                   
                                et al       
                                (74) Representative   
(84)    Designated State                   
                           
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    HONEY & BLANCKENBERG   
    SD    SZ    T Z    UG    ZM    ZW               
(51)    International    Classification    A61K31/506 (2006.01)    C07D401/14 (2006.01)   
                            C07D405/14 (2006.01)    C07D409/14 (2006.06)   


(54)    Title

Subsituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase.

(57)    Abstract

This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

(56)    Documents Cited :    WO 03/076395 A    WO 03/076422 A    WO 03/076438 A

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