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(11)    Patent No :    AP 2332   
(21)    Application No :    AP/P/2007/003906   
(22)    Filing Date :    15.08.2005   
(24)    Date of Grant &    05.12.2011   
           
(45)    Publication :

(30)    Priority Data

(33) Country    (31) Number    (32) Date
US            60/605,244    26.08.2004
US            60/690,803    14.06.2005
   
(84)  Designated State   
GM    GH    KE    LS   MW  MZ    SL   SD   SZ
T Z    UG    ZW       
 

(73) Applicant(s)

PFIZER INC., 235 East 42nd Street , New York, New York 10017,
United States of America

(72) Inventors

CUI Jingrong Jean, United States of America FUNK Lee Andrew, United States of America JIA Lei, United States of America

et al

(74) Representative

GALLOWAY & COMPANY

ZIMBABWE
 

(51)  International  Classification   C07D401/14 (2006.01)    C07D401/04 (2006.01)
A61K31/4439 (2006.01)    A61P35/00 (2006.01)


(54)    Title

Pyrazole -substituted aminoheteroaryl compounds as protein kinase inhibitors.

(57)    Abstract

Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

(56)    Documents Cited :    WO 2004/076412    WO 2004/013091    WO 03/066608

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