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(11)    Patent No :    AP 2320   
(21)    Application No :    AP/P/2006/003770   
(22)    Filing Date :    29.04.2005   
(24)    Date of Grant &    07.11.2011   
           
(45)    Publication :

(30)    Priority Data

(33) Country    (31) Number    (32) Date
US            60/570,300    12.05.2004
US            60/664,305    21.03.2005
   
(84)  Designated State   
GM    GH    KE    LS   MW  MZ    SL   SD   SZ
T Z    UG    ZW       
 

(73) Applicant(s)

PFIZER PRODUCTS INC., Eastern Point Road, Groton, CT 06340,
United States of America

(72) Inventors

HULIN Bernard, United States of America

PIOTROWSKI David Walter, United States of

America

(74) Representative

GALLOWAY & COMPANY

ZIMBABWE
 

(51)  International  Classification   C07D401/14 (2006.01)    C07D413/14 (2006.01)
C07D487/04 (2006.01)    C07D 403/14 (2006.01)
C07D 417/14 (2006.01)   

(54)    Title

Proline derivatives and their use as dipeptidyl peptidase IV inhibitors

(57)    Abstract

The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.

(56)    Documents Cited :    WO 2003/000250 A    EP 1 308 438 A    WO 2004/005291

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