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(11)    Patent No :    AP 2287    (73) Applicant(s)       
(21)    Application No :    AP/P/2006/003579    F. HOFFMANN-LA ROCHE LTD, Grenzacherstrasse 124,       
            4070 Basel,       
(22)    Filing Date :    13.10.2004    Switzerland       
(24)    Date of Grant &    19.09.2011           
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    ANDREWS Steven, Wade, United States of America   
    US            60/511,541        14.10.2003    BLATT Lawrence M, United States of America   
    US            60/612,460        22.09.2004       
                            CONDROSKI Kevin Ronald, United States of   
                                et al       
                                (74) Representative   
(84)    Designated State                   
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    GILL, GODLONTON & GERRANS   
    SD    SZ    T Z    UG    ZM    ZW        ZIMBABWE       
(51)    International    Classification    A61K38/00 (2006.01)    C08H1/00 (2006.01)   

(54)    Title

Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication

(57)    Abstract

The present invention provides compounds of the general formulas I-IX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The present invention further provides treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject

(56)    Documents Cited :    WO 2003/066103 A    US 6 608 027 A    WO 2003/053349 A2


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