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(11)    Patent No :    AP 2280   
(21)    Application No :    AP/P/2005/003474   
(22)    Filing Date :    23.06.2004   
(24)    Date of Grant &    09.09.2011   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/480,988    23.06.2003
(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)
GERON CORPORATION, 230 Constitution Drive, Menlo

Park, 94025, California,
United States of America
(72) Inventors

HARLEY Calvin B, United States of America

CHIN Allison C, United States of America

AKAMA Tsutomu, United States of America

et al

(74) Representative

FISHER CORMACK & BOTHA

(51)  International  Classification   A61K 31/70 (2006.01)    C07J1/00 (2006.01)

(54)    Title

Compositions and methods for increasing telomerase activity

(57)    Abstract

The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.

(56)    Documents Cited : IONKOVA I ET AL: PHYTOCHEMISTRY, PERGAMON PRESS, GB. VOL. 45, NO.8,1 I AUGUST

1997 PP 1597-1600. ABDALLAH R M ET AL: DIE PHARMAZEUTISCHER VERLAG GMBH, ESCHBORN, DE, VOL.48, NO.6 1 JANUARY 1993 PP 452-454. US 5 770 578 A

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