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(11)    Patent No :    AP 2267   
(21)    Application No :    AP/P/2008/004594   
(22)    Filing Date :    02.03.2007   
(24)    Date of Grant &    02.08.2011   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/778,107    02.03.2006

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

SIGA TECHNOLOGIES, INC., 4575 SW Research Way, Suite 230, Corvallis, or 97333,
United States of America

(72) Inventors

HRUBY Dennis E, United States of America

BOLKEN Tove, United States of America

AMBERG Sean, United States of America

et al

(74) Representative


(51)  International  Classification   A61K 31/4164 (2006.01)    A61P 31/14 (2006.01)

(54)    Title

Antiviral drugs for treatment of arenavirus infection.

(57)    Abstract

Compounds, methods and pharmaceutical compositions for treating viral: infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and method's using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Gua-narito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

(56)    Documents Cited :    US 2005/0187390 A1    US 2003/0134853 A1    US 2005/0171038 A1    US 4 492 708 A


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