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(11)    Patent No :    AP 2261   
(21)    Application No :    AP/P/2007/004147   
(22)    Filing Date :    14.03.2005   
(24)    Date of Grant &    26.07.2011   
(45)    Publication :

(30)    Priority Data

(33) Country  (31) Number   (32) Date
(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW
(73) Applicant(s)

SHIRE CANADA INC., Suite 500, 2250 Alfred- Nobel

Boulevard, Ville St-Laurent, Quebec H4S 2C9,

(72) Inventors

SIMION Ioana (legal representative of Dan Simion, deceased.), Canada

CIMPOIA Alex, Canada

(74) Representative

(51)    International  Classification   C07D 411/04 (2006.01)

(54)    Title

Process and methods for the preparation of optically active CIS-2-hydroxymethyl-4-(cytosin -1'-YL)-1,3- oxathiolane or pharmaceutically acceptable salts thereof.

(57)    Abstract

There is provided a method for resolving a compound of formula III, in the cis

configuration. There is also provided a process for producing optically active compound of formula I or II: wherein: RI, R2, RS are as defined herein the method and process involving the production, recovery and conversion of

(56)    Documents Cited : Tetrahedron letters 1994, 35(270, 4739-4742 (Wang, w et -al) (Biochem Therapeutic Inc.)


2095613 A    Bioorg. Med. Chem. Let., 1993,3(8), 1723-1728 (belleau, b et-al) (Biochem


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