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(11)    Patent No :    AP 2241    (73) Applicant(s)       
(21)    Application No :    AP/P/2006/003790    PFIZER PRODUCTS INC., Eastern Point Road, Groton,       
            Connecticut 06340,       
(22)    Filing Date :    02.05.2005    United States of America       
(24)    Date of Grant &    01.06.2011           
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    KATH John Charles, United States of America   
    US            60/571,312    14.05.2004    LUZZIO Michael Joseph, United States of America   
                        (74) Representative   
(84)    Designated State           
    GM    GH    KE    LS   MW  MZ    SL   SD   SZ    GALLOWAY & COMPANY   
    T Z    UG    ZW            ZIMBABWE       
(51)    International    Classification    C07D401/14 (2006.01)    C07D403/12 (2006.01)   
                    C07D303/14 (2006.01)       

(54)    Title

Pyrimidine derivatives for the treatment of abnormal cell growth

(57)    Abstract

The present invention relates to a compound of the formula (I) wherein R' -R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

(56)    Documents Cited :    WO 03/030909 A    WO 04 056807 A    C.T. SUPURAN; A SCOZZAFAVA: Expert opin. Ther.

Patents, Vol. 14, No.1 Jan 2004, pp35-53


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