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(11)    Patent No :    AP 2219   
(21)    Application No :    AP/P/2007/004098   
(22)    Filing Date :    23.09.2005   
(24)    Date of Grant &    22.03.2011   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
IN    472/DEL/2005    04.03.2005

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 

(73) Applicant(s)

FRESENIUS KABI ONCOLOGY LIMITED, B-310, Som Datt

Chambers-1, Bhikaji Cama Place, New Delhi, Delhi- DL,
India 110066,

India
(72) Inventors

MAIKAP Golak Chandra, India

BHATT Deependra, India

PANDA Bijan Kumar, India

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   C07H 13/08 (2006.01)    C07H 19/073 (2006.01)

(54)    Title

Intermediate and process for preparing of beta-anomer enriched 21 deoxy, 21,21 -difluoro-D-ribofuranosyl nucleosides

(57)    Abstract

A highly stereoselective, simple and economical glycosylation process for preparation of beta-anomer enriched 21 -deoxy-21,21 -D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable salts thereof, in particular, the beta- enriched anomer of gemcitabine hydrochloride of formula (lIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I)

(56)    Documents Cited :    US 5 401 861 A    US 5 256 798 A    EP 0 577 303 A

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