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(11)    Patent No :    AP 2204   
(21)    Application No :    AP/P/2006/003810   
(22)    Filing Date :    25.04.2005   
(24)    Date of Grant &    07.02.2011   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/568,872    06.05.2004

(84)    Designated State

GM    GH    KE   LS   MW  MZ   SL   SD   SZ
T Z    UG    ZW
 

(73) Applicant(s)

WARNER-LAMBERT COMPANY LLC, 201 Tabor Road,

Morris
United States of America

72) Inventors

FAKHOURY Stephen Alan, United States of America LEE Helen Tsenwhei, United States of America REED Jessica Elizabeth, United States of America et al

(74) Representative

GALLOWAY & COMPANY

ZIMBABWE
 
(51)  International  Classification   C07D239/94 (2006.01)    C07D401/12 (2006.01)
C07D239/00 (2006.01)   


(54)    Title

4-phenylamino-quinazolin-6-yl-amides

(57)    Abstract

The invention provides quinazoline compounds of the formula: wherein RI is halo; R2 is H or halo; R3 is a) CrC3 alkyl, optionally substituted by halo; orb) -(CH2)n-morpholino, -(CH2)n-piperidine, -(CH2)n-piperazine, -(CH2)n-piperazine-N(C1 -C3 alkyl), -(CH2)n -pyrrolidine, or -(CH2)n imidazole; n is 1 to 4; R, is -(CH2)m-Het; Het is morpholine.piperidine, piperazine, piperazine-N(CrC3 alkyl), imidazole,pyrrolidine, azepane,

3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1 -C3 alkyl) or N (C1 -C3alkyl)2; m is 1-3; an d X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

(56)    Documents Cited :    WO 96/33980 A    WO 97/38983 A    WO 2004/069791 A1

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