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(11)    Patent No :    AP 2184   
(21)    Application No :    AP/P/2006/003536   
(22)    Filing Date :    20.08.2004   
(24)    Date of Grant &    02.12.2010   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/500,144    09.03.2003
(84)    Designated State

GM    GH    KE   LS   MW  MZ   SL   SD   SZ
T Z    UG    ZW

(73) Applicant(s)

PFIZER INC., 235 East 42nd Street , New York, New York 10017,
United States of America

(72) Inventors

IGUCHI Satoru, Japan

KATSU Yasuhiro, Japan

KOJIMA Takashi, Japan

et al

(74) Representative



(51)  International  Classification   C07D 401/12 (2006.01)    C07D 405/06 (2006.01)
A61P 1/04 (2006.01)   

(54)    Title

Benzimidazolone compounds having 5-HT4 receptor agonistic activity

(57)    Abstract

This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the

use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian,

(56)    Documents Cited :    EP 0 522 914 A   WO 00/37461 A   WO 02/053568 A


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