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(11)    Patent No :    AP 2139   
(21)    Application No :    AP/P/2006/003795   
(22)    Filing Date :    31.03.2005   
(24)    Date of Grant &    21.08.2010   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/559,250    02.04.2004

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

OSI PHARMACEUTICALS, INC., 41 Pinelawn Road, Melville,

United States of America
(72) Inventors

ARNOLD Lee Daniel, United States of America

COATE Heather, United States of America

et al

(74) Representative


(51)    International  Classification   A61K 36/00 (2006.01)

(54)    Title

6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors

(57)    Abstract

Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein X,, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
(56)    Documents Cited :    WO 2005 061519 A    WO 2005 037836 A    WO 2004 056830 A


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