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(11)    Patent No :    AP 2138    (73) Applicant(s)       
(21)    Application No :    AP/P/2006/003799    CELGENE CORPORATION, 86 Morris Avenue, Summit,       
            07901, New Jersey,       
                   
(22)    Filing Date :    14.04.2004    United States of America       
(24)    Date of Grant &    22.07.2010           
                   
(45)    Publication :

(30)    Priority Data            (72) Inventors   
    (33) Country    (31) Number    (32) Date    ZELDIS Jerome B, United States of America   
                (74) Representative   
(84)    Designated State           
                   
    BW  GM  GH    KE   LS   MW    MZ   SL   SD    FISHER CORMACK & BOTHA   
    SZ   T Z   UG   ZM   ZW               
(51)    International    Classification    A61K31/724 (2006.01)    A61K31/454 (2006.01)   
            A61K31/496 (2006.01)       
(54)    Title

Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes

(57)    Abstract

Methods of treating, preventing and/or managing myelodyspjastic syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient, and/or the transplantation of blood or cells. Specific second active ingredients are capable of affecting or blood cell production. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

(56)    Documents Cited :    US 5288487 A    WO 92/06712 A1    US 6281230 B1

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