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(11)    Patent No :    AP 2092   
(21)    Application No :    AP/P/2002/002690   
(22)    Filing Date :    05.06.2001   
(24)    Date of Grant &    18.01.2010   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
GB    0013810.7    06.06.2000

(84)    Designated State

GM    GH    KE   LS   MW  MZ   SL   SD   SZ
T Z    UG    ZW
 
(73) Applicant(s)

CELLTECH R&D LIMITED, 208 Bath Road, Slough,

Berkshire SL1 3WE,
United Kingdom

(72) Inventors

ATHWAL Diljeet Singh, United Kingdom

BROWN Derek Thomas, United Kingdom

WEIR Andrew Neil Charles, United Kingdom

et al

(74) Representative

FISHER CORMACK & BOTHA
 
(51)  International  Classification   C12N 15/13 (2006.01)    C07K 16/24 (2006.01)
C07K 16/46 (2006.01)    A61K 47/48 (2006.01)
C12N 15/62 (2006.01)    C12N 15/70 (2006.01)
A61K 39/395 (2006.01)   

(54)    Title

Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof.

(57)    Abstract

There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFa. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFa.


(56)    Documents Cited :    WO 99 64460 A    WO 98 25971 A    WO 92 11383 A

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