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(11)    Patent No :    AP 2070   
(21)    Application No :    AP/P/2004/003166   
(22)    Filing Date :    04.04.2003   
(24)    Date of Grant &    09.12.2009   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    10/116,117    05.04.2002

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

NOVARTIS VACCINES AND DIAGNOSTICS, INC, 4560

Horton Street, Emeryville, CA 94608-2916,
United States of America

(72) Inventors

RENHOWE Paul A., United States Of America

PECCHI Sabina, United States Of America

MACHAJEWSKI Timothy D., United States Of
America

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   A61K 31/19 (2006.01)    A61K 31/47 (2006.01)
C07D 487/08 (2006.01)   


(55)    Title

Quinolinone derivatives

(57)    Abstract

Organic compounds having the formulas (I) and (II) are provided where the variables have the values described herein. Medicaments include an anti-cancer drug selected from 5-FU or CPT 11 and a compound of formula

(I)

or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in

treatin along with an anti-cancer drug selected from 5-FU or CPT -11. The medicaments may be used in treating cancer. The use of a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of

(56)    Documents Cited :    WO 00/71129 A   WO 02/22598 A   WO 01 289993 A

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