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(11)    Patent No :    AP 2069   
(21)    Application No :    AP/P/2008/004679   
(22)    Filing Date :    22.06.2007   
(24)    Date of Grant &    08.12.2009   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    06116003.2    23.06.2006

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 
(73) Applicant(s)

TIBOTEC PHARMACEUTICALS LTD., Eastgate Village,

Eastgate, Little Island, Co Cork,
Ireland

(72) Inventors

DE KOCK Herman Augustinus, Belgium

JONCKERS Tim Hugo Maria, Belgium

BOONANTS Paul Jozef Gabriel Maria, Belgium

et al

(74) Representative

HONEY & BLANCKENBERG
 
(51)  International  Classification   C07D493/04 (2006.01)    A61K 31/34 (2006.01)
A61P 31/18 (2006.01)   


(54)    Title

2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors

(57)    Abstract

The present invention relates to 2 -(substituted-amino)-benzothiazole sulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present inve ntion also concerns combinations of the present 2-(substituted-amino)-

benzothiazole sulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.


(56)    Documents Cited :    WO 03/049746 A   WO 02/083657 A

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