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(11)    Patent No :    AP 2065   
(21)    Application No :    AP/P/2005/003366   
(22)    Filing Date :    04.02.2004   
(24)    Date of Grant &    26.11.2009   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    PCT/EP03/01291    07.02.2003

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 

(73) Applicant(s)

JANSSEN PHARMACEUTICA N.V., Turnhoutseweg 30, 2340

Beerse,
Belgium
(72) Inventors

HEERES Jan, Belgium

LEWI Paulus Joannes, Belgium

DE JONGE Marc René, The Netherlands

et al

(74) Representative

HONEY & BLANCKENBERG

(51)  International  Classification   A61P 31/18 (2006.01)    C07D239/46 (2006.01)

(54)    Title

Pyrimidine derivatives for the prevention of HIV infection

(57)    Abstract

This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a1=a2-a3-a4- and -b1=b2=b3=b4 - represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl: and pharmaceutical compositions comprising them.

(56)    Documents Cited :    WO 99 50250 A   WO 03 016 306 A

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